Sensitive and broadly applicable residual disease detection in acute myeloid leukemia using flow cytometry-based leukemic cell enrichment followed by mutational profiling
- Authors
- Daga S, Rosenberger A, Kashofer K, Heitzer E, Quehenberger F, Halbwedl I, Graf R, Krisper N, Prietl B, Höfler G, Reinisch A, Zebisch A, Sill H, Wölfler A. Sensitive and broadly applicable residual disease detection in acute myeloid leukemia using flow cytometry-based leukemic cell enrichment followed by mutational profiling. Am J Hematol. 2020 Oct;95(10):1148-1157. doi: 10.1002/ajh.25918. Epub 2020 Aug 10. PMID: 32602117; PMCID: PMC7540028.
- Journal
- American Journal of Hematology
- Published
Abstract
This study presents a sensitive approach for residual disease detection in AML. It combines flow cyometry based leukemic cell enrichment with mutational profiling. Technologies used at CBmed: multi-parameter FACS analysis and advanced data analysis / data science.