Characterization of Inflammatory Mediators and Metabolome in Interstitial Fluid Collected with Dermal Open Flow Microperfusion before and at the End of Dupilumab Treatment in Atopic Dermatitis
- Authors
- Monedeiro F, Ehall B, Tiffner K, Eberl A, Svehlikova E, Prietl B, Pfeifer V, Senekowitsch J, Remm A, Rebane A, Magnes C, Pieber T, Sinner F, Birngruber T. Characterization of Inflammatory Mediators and Metabolome in Interstitial Fluid Collected with Dermal Open Flow Microperfusion before and at the End of Dupilumab Treatment in Atopic Dermatitis. J Proteome Res. 2024 Aug 2;23(8):3496-3514. doi: 10.1021/acs.jproteome.4c00153. Epub 2024 Jul 10. PMID: 38986055; PMCID: PMC11304394.
- Journal
- Journal of Proteome Research
- Published
Abstract
This study characterizes inflammatory mediators and metabolites in interstitial fluid before and after dupilumab therapy in atopic dermatitis. Dermal open flow microperfusion is used for longitudinal profiling. Technologies used at CBmed: multi-parameter FACS analysis and advanced data analysis / data science.