Micro- and nanoplastic particles (MNP) have been found in recent years in all parts of the world and in various organisms. In the human body MNP have been detected e.g. in stool, placenta, kidney or lungs – not surprising considering that we consume on average up to 5 grams (!) of MNP per week. Until now, the health effects of this exposure to MNP are almost completely unexplored, especially regarding tumor development, growth and dissemination.
microONE was designed to fill this substantial knowledge gap within a multinational, multidisciplinary, cross-sectorial approach. It aims to provide scientific evidence on whether – and if so, how – different particles influence tumor development and spread by using colorectal cancer (CRC), one of the most frequent tumor entities and prone to contact with MNP in the gut, as an example.
Hence, major objectives of microONE are: