Core
Technologies
Precision medicine technologies are crucial for enabling personalized treatment plans tailored to each patient’s unique characteristics.
Precision Medicine Technologies
CBmed’s in-house precision medicine laboratories encompass all wet lab objectives in immunology, including flow cytometry (FACS), tissue-based imaging (both single- and multi-plex fluorescent immunohistochemistry), advanced 2D and 3D cell culture, ex-vivo compound screening, and live cell imaging. Our commitment to high-quality standards ensures consistent reproducibility, with all technologies integrated into our laboratory information and management system.
Additionally, our wet labs collaborate closely with the CBmed data science group, which brings expertise in biostatistics, computational biology, data engineering, machine learning, and DevOps. This multidisciplinary approach aims to develop advanced data analysis workflows.
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Focus on immune phenotyping technologies
Single- and multiplex immunofluorescent staining as well as flow cytometry are commonly used in immunophenotyping to characterize the immune profile of cells, analyze cell populations, and study protein expression and localization.
Immunofluorescence refers to techniques using antibodies conjugated to fluorescent dyes to detect specific antigens in cells or tissue samples.
Flow Cytometry involves labeling cells with fluorescent antibodies and passing them through a laser beam to measure and analyze the expression of specific antigens on the cell surface or within cells.
Both methods can be used with single antibodies (single staining, singe-parameter analysis) or with multiple antibodies simultaneously (multiplex staining, multi-parameter analysis.
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Technologies
By integrating our advanced technologies with robust quality systems and a commitment to reproducibility, we drive the advancement of precision medicine through innovative technology development, research, and comprehensive data analysis.
Frequently Asked Questions
What are Core Technologies at CBmed?
CBmed’s Core Technologies comprise a suite of advanced laboratory and analytical methods enabling high quality precision medicine research. These include flow cytometry, immunohistochemistry, immunofluorescence, 2D/3D cell culture, live cell imaging, standard molecular and cellular assays, and compound screening. Together, they provide the experimental foundation for deep biological insight and patient tailored research.
How do Core Technologies support biomarker discovery?
By combining multi platform data – including immunophenotyping, metabolomics, imaging, and molecular analysis – with rigorous quality standards, CBmed’s Core Technologies generate comprehensive biological profiles. These datasets help researchers identify, validate, and prioritize biomarkers that are relevant for disease staging, prognosis, and therapeutic decision making.
What role does immunofluorescence play in Core Technologies?
Immunofluorescence enables the visualization of specific proteins or cellular structures using fluorescently labeled antibodies. This technique provides high resolution spatial information, supporting detailed immune profiling and mechanistic studies that help clarify disease pathways.
How is the LSRFortessa flow cytometer used within CBmed’s Core Technologies?
The LSRFortessa enables rapid, multiparametric analysis of individual cells. By measuring fluorescence signals from labeled antibodies as cells pass through laser detectors, it allows precise quantification and characterization of cell populations, immune subsets, and signaling states.
Why do Core Technologies include advanced 2D and 3D cell culture models?
2D monolayer cultures and 3D spheroid models recreate biological conditions at different levels of complexity. Especially 3D cultures more closely mimic human tissue architecture and tumor microenvironments, enabling more predictive studies of cell behavior, drug responses, and disease mechanisms.
How do Core Technologies integrate with data science at CBmed?
Core Technologies produce rich, high dimensional datasets that feed directly into CBmed’s data science pipelines. Using biostatistics, computational biology, and machine learning, these datasets are transformed into actionable insights – supporting biomarker discovery, treatment stratification, and precision medicine innovation.